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Nationwide, at least 45 million people ages 12 and older, or one out of five adolescents and adults, have had genital HSV infection.Between the late 1970s and the early 1990s, the number of Americans with genital herpes infection increased 30 percent.

Genital HSV-1 outbreaks recur less regularly than genital HSV-2 outbreaks. There is no treatment that can cure herpes, but antiviral medications can shorten and prevent outbreaks during the period of time the person takes the medication.Genital HSV-2 infection is more common in women (approximately one out of four women) than in men (almost one out of five).This may be due to male-to-female transmissions being more likely than female-to-male transmission. HSV-1 and HSV-2 can be found in and released from the sores that the viruses cause, but they also are released between outbreaks from skin that does not appear to be broken or to have a sore.When signs do occur, they typically appear as one or more blisters on or around the genitals or rectum.The blisters break, leaving tender ulcers (sores) that may take two to four weeks to heal the first time they occur.